Monoclonal Anti-Na⁺/K⁺ ATPase (α1 Subunit) antibody produced in mouse

产品说明

一般描述

Mouse Monoclonal Anti-Na⁺/K⁺ ATPase (α1 Subunit) antibody localizes the Na⁺/ K⁺ ATPase α1 subunit in human, canine, rat and avian tissues.
The gene coding Na⁺,K⁺-ATPase is mapped to human chromosome 1p13.1, which is a plasma membrane ion transporter. It is ubiquitously expressed in all animals. The α subunit of the protein consists of 10 transmembrane helices, and three cytoplasmic domains A, N and P that serve as actuator, in nucleotide-binding and for phosphorylation, respectively.
Na⁺/K⁺ transporting ATPase subunit α1 is an ion transport pump critical for maintaining the gradient of Na and K ions across the plasma membrane.
Epitope mapping studies indicate the antibody binds within the intracellular region at or near Asp-369 of the α subunit. Staining is consistent with the plasma membrane localization of Na⁺/K⁺ ATPase.

免疫原

rat kidney Na⁺/K⁺ ATPase.

应用

Mouse Monoclonal Anti-Na⁺/K⁺ ATPase (α1 Subunit) antibody has been used for immunohistochemical assays. It has also been used for immunolabeling assays to quantify the expression of proteins involved in cellular ion transport. Furthermore, the product is suitable for use in indirect ELISA.
Monoclonal Anti-Na⁺/K⁺ ATPase (α1 Subunit) antibody produced in mouse has been used in immunohistochemistry.

生化/生理作用

Na⁺,K⁺-ATPase facilitates the transport of Na⁺ and K⁺ ions across plasma membrane in an ATP-dependent manner. Therefore, it is responsible for maintaining ion homeostasis across the cell and controls cellular excitability in electrically active tissues. The Na⁺ potential established by Na⁺,K⁺-ATPase is required for the function of secondary active transporters. Variation in the gene mostly results in protein function alteration, otherwise in some cases its stability, expression or plasma membrane targeting property is affected. Mutation in the gene is known to cause a number of disease conditions including Familial Hemiplegic Migraine type 2, Rapid-onset Dystonia Parkinsonism and Alternating Hemiplegia of Childhood. Na⁺,K⁺-ATPase serves as a receptor for cardiotonic steroids, that play a vital role in triggering proinflammatory cytokine production, in chronic inflammatory diseases, such as atherosclerosis.

外形

Solution in phosphate buffered saline containing 0.05% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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