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Anti-phospho-STAT3 (Tyr68) Antibody

品牌
Sigma-Aldrich
货号
07-1347
规格纯度
from rabbit, purified by affinity chromatography
参考价格
5016.79 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

This protein is a member of the family of STAT proteins (Signal Transduction and Activators of Transcription). These proteins are latent cytoplasmic transcription factors with the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. The N-terminal region is highly homologous among the STAT proteins and surrounds a completely conserved arginine residue. The Stat3 protein is expressed in most cell types and is activated by multiple cytokines and growth factors including: IFN-a, IL-10, IL-6, IL-11, onM, LIF, CNTF, G-CSF, IL-12, IL-2, GH, EGF, PDGF, and CSF-1. Stat3 is not activated by IFN beta. One active Stat3 translocates to the nucleus and binds to DNA as either a homodimer or as a heterodimer with Stat1. Transcription factors associated with Stat3 include cJun and cyclic AMP responsive enhancer binding protein (CREB). Stat3 interacts with the APRE (acute phase response element) and the SIE (c-sis inducible element).

特异性

This antibody recognizes STAT3 phosphorylated at Tyr68.

免疫原

KLH-conjugated linear peptide corresponding to human STAT3 phosphorylated at Tyr68.
Epitope: Phosphorylated Tyr68

应用

Research Sub Category
Transcription Factors
Research Category
Epigenetics & Nuclear Function

Signaling
Detect phospho-STAT3 (Tyr68) using this Anti-phospho-STAT3 (Tyr68) Antibody validated for use in WB.

质量

Evaluated by Western Blot in PMA treated and untreated MOLT4 cell lysates.

Western Blot Analysis: 5 µg/mL of this antibody detected STAT3 on 10 µg of PMA treated and untreated MOLT4 cell lysates.

目标描述

~75 kDa observed

外形

Antigen Affinity
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
PMA treated and untreated MOLT4 cell lysates

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

生物来源rabbit
质量水平100
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
纯化方式affinity chromatography
species reactivityhuman, pig
species reactivity (predicted by homology)mouse (based on 100% sequence homology), chicken (based on 100% sequence homology), bovine (based on 100% sequence homology), rat (based on 100% sequence homology), Xenopus (based on 100% sequence homology), zebrafish (based on 100% sequence homology), porcine (based on 100% sequence homology)
technique(s)western blot: suitable
NCBI登记号NP_003141
UniProt登记号P40763
运输wet ice
Gene Informationhuman ... STAT3(6774)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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