产品说明
一般描述
CENP-A is a variant version of histone H3 found only at centromeres.
Centromere protein A (CENP-A) is a 17 kDa centromere-specific histone variant with 62% amino acids homology to the C-terminal of histone H3. Localized in the centromere, it plays a central role in the centromere-specific chromatin formation. The depletion of histone H3 at the CENP-A binding domain suggests CENP-A to be a possible replacement for histone H3 in the packaging process of α-satellite DNA into primary chromation structure. CENP-A is essential in the formation of specialized nucleosomes at the centromere, implicating CENP-A as a centromere-specific epigenetic marker.
特异性
CENP-A
Broad species cross-reactivity is predicted.
免疫原
peptide (RRRSRKPEAPRRRS) corresponding to amino acids 4-17 of human CENP-A
应用
Anti-CENP-A Antibody is a Rabbit Polyclonal Antibody for detection of CENP-A also known as Centromere autoantigen A & has been tested in WB.
Research Sub Category
Cell Cycle, DNA Replication & Repair
Research Category
Epigenetics & Nuclear Function
质量
routinely evaluated by immunoblot in acid extracted histones from HeLa cells
目标描述
17kDa
联系
Replaces: 04-205
外形
Affinity purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide.
ImmunoAffinity Purified
储存及稳定性
Stable for 1 year at 2 to 8ºC from date of receipt.
分析说明
Control
Control Histones (from Hela cells) colcemid-treated or untreated
法律信息
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
eCl@ss | 32160702 |
NACRES | NA.41 |
产品性质
生物来源 | rabbit |
质量水平 | 100 |
抗体形式 | affinity purified immunoglobulin |
antibody product type | primary antibodies |
克隆 | polyclonal |
纯化方式 | affinity chromatography |
species reactivity | human |
manufacturer/tradename | Upstate® |
technique(s) | western blot: suitable |
同位素/亚型 | IgG |
NCBI登记号 | NM_001809 |
UniProt登记号 | P49450 |
运输 | wet ice |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 1 |