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Anti-Galectin-8 antibody, Mouse monoclonal antibody produced in mouse

品牌
Sigma-Aldrich
货号
G5671
规格纯度
~1.0 mg/mL, clone VA-11.25, purified from hybridoma cell culture
参考价格
4574.61 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Galectins specifically bind to β-galactosides. 15 mammalian galectins have been identified so far. Galectin 8 contains two CRDs connected by a short linker peptide.
Monoclonal Anti-Galectin 8 (mouse IgM isotype) is derived from the hybridoma VA-11.25 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant rat galectin 8.Galectins belong to a family of carbohydrate-binding proteins. Within this family of proteins, galectin 8 is unique, as it exists in many forms encoded by the same gene.

特异性

The antibody has low cross-reactivity with galectin 3 and galectin 9.

免疫原

recombinant rat galectin 8.

应用

Monoclonal Anti-galectin-8 antibody produced in mouse has been used for:

  • immunoblotting
  • immunocytochemistry
  • enzyme linked immunosorbent assay (ELISA)

生化/生理作用

Galectins belong to a family of carbohydrate-binding proteins. These proteins share similarities in the carbohydrate recognition domain (CRD) and in their specificity for N-Acetyllactosamine-enriched glycoconjugates. The binding of galectins to saccharides modulates cell proliferation, cell death and cell migration, which are involved in cancer initiation and progression. Galectin 8 is a secreted protein that requires both of its CRDs to be active to modulate cell adhesion. It forms a complex with integrins and triggers integrin-mediated signaling cascades. On the contrary, excessive amounts of this protein negatively regulate cell adhesion by interacting with integrins. These signals assist in identifying regions available for cell adhesion and migration. It may be involved in neoplastic transformation.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆VA-11.25, monoclonal
形式buffered aqueous solution
分子量antigen ~34 kDa
species reactivityrat, human, mouse
浓度~1.0 mg/mL
technique(s)immunocytochemistry: suitable
indirect ELISA: suitable
western blot: 1-2 μg/mL using rat galectin 8 recombinant protein
同位素/亚型IgM
UniProt登记号O00214
运输dry ice
储存温度−20℃
Gene Informationhuman ... LGALS8(3964)
mouse ... Lgals8(56048)
rat ... Lgals8(116641)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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