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Monoclonal Anti-GABRB3 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB5200049
规格纯度
clone S87-25, 1 mg/mL, purified immunoglobulin
参考价格
5045.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The γ-aminobutyric acid type A receptor β3 subunit (GABRB3) gene with nine exons spanning 250kb, is mapped to human chromosome 15q12, a hot region of genomic rearrangements. The gene codes for β3 subunit of GABAA receptor, which belongs to the GABA (γ-aminobutyric acid) receptor gene family.

特异性

Detects ~55 kDa. No cross-reactivity against GABA-A-R-Beta 2 or –Beta1.

免疫原

Fusion protein amino acids 370-433 of mouse GABA-A_r Beta3, Accession Number AAB60502.

生化/生理作用

γ-aminobutyric acid type A receptor β3 subunit (GABRB3) is a candidate gene for autism spectrum conditions (ASC). Alteration in the gene results in increased tactile sensitivity, or hypersensitivity. Overexpression of GABRB3 might be implicated in the pathogenesis of heroin dependence. Aberration or mutation of this gene leads to neurodevelopmental disorders, such as Angelman syndrome, Prader-Willi syndrome and schizophrenia. GABRB3 polymorphisms results in nonsyndromic cleft lip and/or palate (NSCL/P).

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆S87-25, monoclonal
形式buffered aqueous glycerol solution
分子量antigen predicted mol wt 55 kDa
species reactivitymouse, human, rat
浓度1 mg/mL
technique(s)immunocytochemistry: suitable
western blot: suitable
同位素/亚型IgG1
NCBI登记号NP_032097.1
UniProt登记号P28472
运输wet ice
储存温度−20℃
Gene Informationmouse ... Gabrb3(14402)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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