产品说明
一般描述
CD68 is an intracellular glycoprotein mainly expressed on macrophages and monocytes. It could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is also expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML) (M1-M5 types), and granulocytic sarcoma.
CD68 (cluster of differentiation 68) gene is mapped to human chromosome 17p13.1. The gene codes for a glycoprotein, macrosialin. The encoded protein belongs to the family of LAMP (lysosome-associated membrane glycoproteins) proteins. Macrosialin contains a glycosylated mucin-like domain.
免疫原
Synthetic peptide derived from the internal region of the human CD68 protein.
应用
Monoclonal Anti-CD68 antibody from rabbit has been used for immunohistochemistry.
生化/生理作用
CD68 (cluster of differentiation 68), a scavenger receptor, significantly participates in the development of Alzheimer′s disease. CD68 serves as a prognostic marker in tumor cells. Deletion of the gene is known to cause reduction in the bone resorption capacity.
特点和优势
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外形
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 重组 | expressed in proprietary host |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | SP251, monoclonal |
| species reactivity | human (tested) |
| technique(s) | flow cytometry: 1:100 immunohistochemistry: 1:100 |
| 同位素/亚型 | IgG |
| UniProt登记号 | P34810 |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| Gene Information | human ... CD68(968) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
