Anti-Deptor antibody produced in rabbit

产品说明

一般描述

Deptor is made up of disheveled/egl-10/pleckstrin (DEP) domains and one post-synaptic density-95/discs large/zonula occludens-1 (PDZ) domain.
DEPTOR (DEP domain containing MTOR-interacting protein) is a tumor suppressor and mTOR-binding protein. This protein is expressed in vascular endothelial cells.
Deptor is encoded by the gene mapped to human chromosome 8q24.12.

特异性

Anti-Deptor recognizes human, mouse, rat, and canine Deptor.

应用

Anti-Deptor antibody produced in rabbit may be used in immunoblotting.

生化/生理作用

DEPTOR (DEP domain containing MTOR-interacting protein) suppresses mTORC1 (mammalian target of rapamycin complex 1) and mTORC2 proteins which are responsible for the control of cell growth, metabolism, proliferation and survival. It is expressed in normal pancreatic acinar and islet cells, and this expression is completely lost in pancreatic ductal adenocarcinoma (PDAC) tissues. Therefore, it functions as a tumor suppressor in pancreatic cancer. It is regulator of inflammatory and angiogenic responses and controls the activation of vascular endothelial cells. DEPTOR is expressed in placenta, and DEPTOR signaling is influenced by maternal stress which might eventually impact the outcome of pregnancy. The expression of this protein is reduced in thyroid, prostate, bladder and cervical cancer.
Overexpression of the DEPTOR gene inhibits mTORC1. The feedback inhibition of phosphatidylinositol-3-kinase (PI3K), leading to the activation of the PI3K/mTORC2/protein kinase B (Akt) pathway. This protein is highly expressed in multiple myelomas fostering cyclin D1/D3 or c-musculoaponeurotic fibrosarcoma (c-MAF)/musculoaponeurotic fibrosarcoma (MAFB) translocations.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

储存及稳定性

Store at –20 ℃. For continuous use, store at 2–8 ℃ for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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