产品说明
一般描述
Matrilin 1 (MATN1) is also called the cartilage matrix protein (CMP) and is the major matrix component of cartilage. The gene encoding MATN1 is mapped to human chromosome 1p35.2. Matrilin 1 (MATN1) encodes a protein of 52,000 Da and exists as trimer. It has von Willebrand factor A domain. It is a glycoprotein and interacts with cartilage collagen fibrils.
应用
Suitable as a blocking agent using corresponding antibodies.
生化/生理作用
Autoantibodies to Matrilin 1 (MATN1) is implicated in patients with autoimmune disorder, polychondritis. MATN1 inhibits new capillary and blood vessel formation and could be used for treating diseases associated with improper neovascularization. Mutations in MATN1 gene impacts the assembly process of collagen. MATN1 gene polymorphisms result in spine deformity and is associated with familial idiopathic scoliosis
联系
Corresponding Antibody HPA028580.
外形
Solution in 1 M urea-PBS, pH 7.4
制备说明
The protein solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.
法律信息
Prestige Antigens is a trademark of sigma-aldrich Co. LLC
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
产品性质
| 质量水平 | 100 |
| 重组 | expressed in E. coli |
| 测定 | >80% (SDS-PAGE) |
| 形式 | buffered aqueous solution |
| 分子量 | predicted mol wt 26 kDa |
| 纯化方式 | immobilized metal affinity chromatography (IMAC) |
| 浓度 | ≥0.5 mg/mL |
| 免疫原序列 | REIASEPVAEHYFYTADFKTINQIGKKLQKKICVEEDPCACESLVKFQAKVEGLLQALTRKLEAVSKRLAILENTVV |
| 基因组数据库 |人类登记号 | ENSG00000162510 |
| UniProt登记号 | P21941 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... MATN1(4146) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
