产品说明
一般描述
The progesterone receptor (PR) gene is mapped to human chromosome 11q22–23. The gene encodes for two isoforms, namely PR-A and PR-B, each of which is transcribed from a specific promoter region. The encoded receptor belongs to the family of steroid hormone receptors.
Anti-Progesterone receptor antibody detects endogenous levels of total progesterone receptor protein.
免疫原
The antiserum was produced against synthesized peptide derived from human Progesterone Receptor.
Immunogen Range: 261-310
应用
Anti-Progesterone receptor antibody produced in rabbit has been used in western blotting and immunohistochemistry.
生化/生理作用
Progesterone receptor (PR) mediates the actions of progesterone which is essential to maintain pregnancy. PR is known to regulate the genes involved in the process of cell cycle, cell adhesion, invasion, differentiation, proliferation, inflammation, and apoptosis. PR expression might serve as a biomarker in axillary lymph node (ALN) metastasis. Abnormal expression of PR is observed in breast cancer.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD00239723 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 98 kDa |
| species reactivity | human, mouse, rat |
| 浓度 | ~1 mg/mL |
| technique(s) | ELISA: 1:5000 immunofluorescence: 1:100-1:500 immunohistochemistry: 1:50-1:100 |
| NCBI登记号 | P06401 |
| UniProt登记号 | P06401 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PGR(5241) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
