产品说明

一般描述

B2M (β-2-microglobulin) is the invariant light chain of the HLA antigen protein. It is low molecular weight protein. It is a membrane protein found in approximately all nucleated cells. As it is shedded from the cell membranes, it is found in body fluids as well. This gene is localized to human chromosome 6, and the encoded protein has a molecular weight of 11,800Da. It has a loop in its structure, and is composed of 99 amino acids. It is a member of the immunoglobulin (Ig) superfamily.

免疫原

β-2-Microglobulin precursor recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

B2M (β-2-microglobulin) is filtered during glomerular filtrations, and reabsorbed and catabolized by proximal renal tubule. It is therefore, not detectable in urine in normal conditions. Thus, it is a sensitive and early biomarker of acute kidney injury. In patients subjected to long-term hemodialysis, this protein is responsible for systemic amyloidosis. The levels of this protein are altered in the cerebrospinal fluid of patients with neurological diseases such as, leptomeningeal metastasis, purulent meningitis, viral meningitis or encephalitis, and neuroborreliosis. B2M levels are also linked with non-Hodgkin′s lymphoma (NHL), and in patients with NHL, higher levels of B2M the prognosis is poor, and they have higher mortality risk.

特点和优势

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST71133.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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