Anti-60S Ribosomal Protein L26

产品说明

一般描述

60S ribosomal protein L26 (UniProt: P61254) is encoded by the RPL26 gene (Gene ID: 6154) in human. 60S ribosomal protein L26 belongs to the ribosomal protein L24P family and is found in all eukaryotes. It is primarily localized in the cytoplasm, but to a lesser extent it is also found in the nucleoplasm and nucleolus. It associates with the large 60S subunit of the ribosome and contains a KOW motif, a conserved RNA-binding motif present in many ribosomal proteins. 60S ribosomal protein L26 is shown to be involved in translation. Knockdown of RPL26 results in a significant decrease in synthesis of 28S rRNA (associated with 60S subunit). Overexpression of RPL26 is shown to enhance the binding of p53 mRNA to the ribosomes and increase p53 translation, which subsequently leads to cell-cycle arrest at G1 phase and can enhance radiation-stimulated apoptosis. Mutations in RPL26 gene are reported to cause congenital non-regenerative hypoplastic anemia that is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy.

特异性

This polyclonal antibody detects 60S ribosomal protein L26 in human.

免疫原

GST-tagged recombinant fragment corresponding to the first 95 amino acids from human 60S ribosomal protein L26.

应用

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected 60S Ribosomal Protein L26 in human cerebral cortex, human pancreas, and human colon tissues.

Research Category
Epigenetics & Nuclear Function
Anti-60S Ribosomal Protein L26 Antibody, Cat. No. ABE1438, is a highly specific rabbit polyclonal antibody that targets 60S ribosomal protein L26 and has been tested in Immunohistochemistry (Paraffin), and Western Blotting.

质量

Evaluated by Western Blotting in Hek293 cell lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected 60S Ribosomal Protein L26 in 10 µg of HEK293 cell lysate.

目标描述

~17 kDa observed; 17.26 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

外形

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Affinity Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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