产品说明
一般描述
PP2A is a serine/threonine phosphatase that downregulates the MAP kinase pathway and subsequently modulates mitogenic signaling. This phosphatase also mediates localization of Sgo1 at centromeres, Ras-1 activation, and chromosome segregation. The catalytic subunit of PP2A (PP2Ac) regulates the signaling pathway for glucose-stiμLated insulin secretion .
特异性
Monoclonal Anti-PP2Ac is specific for the α and β isoforms of PP2Ac in humans, rats and mice. The antibody has not been tested in other species for cross-reactivity.
应用
MonoclonalAnti-PP2A, C subunit antibody produced in mouse has been used in immunoblotting and immunoprecipitation.
生化/生理作用
Protein phosphatase 2A (PP2A) is implicated in the negative control of cell growth and division. PP2Ac undergoes two post-translational modifications, phosphorylation and methylation, which are involved in the regulation of the enzyme activity.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.44 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| 克隆 | 7A6, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 36 kDa |
| species reactivity | human, mouse, rat |
| 浓度 | ~1.0 mg/mL |
| technique(s) | immunoprecipitation (IP): suitable western blot: 1-2 μg/mL using whole extracts of mouse 3T3, rat Rat2 or human A431 cells. |
| 同位素/亚型 | IgG1 |
| UniProt登记号 | P67775 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PPP2CA(5515) mouse ... Ppp2ca(19052) rat ... Ppp2ca(24672) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
