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Anti-Histone Deacetylase 5 (HDAC5) antibody, Mouse monoclonal

品牌
Sigma-Aldrich
货号
H4538
规格纯度
clone HDAC5-35, purified from hybridoma cell culture
参考价格
5045.46 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Monoclonal Anti-Histone Deacetylase 5 (HDAC5) (mouse IgG1 isotype) is derived from the HDAC5-35 hybridoma produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice immunized with a synthetic peptide. Mammalian HDACs can be divided into three classes according to sequence homology. Class II consists of the yeast Hda1-like proteins HDAC4, HDAC5, HDAC6, HDAC7, HDAC9 and HDAC10. Histone deacetylase 5 (HDAC5) is a histone deacetylase, located on human chromosome 17q21.

应用

Anti-Histone Deacetylase 5 (HDAC5) antibody, Mouse monoclonal has been used in:

  • western blotting
  • immunostaining
  • enzyme-linked immunosorbent assay (ELISA)
  • immunocytochemistry
  • immunoprecipitation

生化/生理作用

Histone deacetylase 5 (HDAC5) promotes progression of the cell cycle, cell proliferation and apoptosis. HDAC5 activity is important for the differentiation of muscle cells by binding, through its N-terminal domain, to the myocyte enhancer factor-2 (Mef2) protein, thus repressing expression of MEF2 downstream genes. Overexpression of HDAC5 in different cancer cells suppresses their growth by induction of apoptosis in a p53-independent manner. Reduced expression of the protein is observed in colon cancer and acute myeloid leukemia.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD04040361
NACRESNA.41

产品性质

质量水平200
生物来源mouse
偶联物unconjugated
抗体形式purified from hybridoma cell culture
antibody product typeprimary antibodies
克隆HDAC5-35, monoclonal
形式buffered aqueous solution
分子量antigen ~124 kDa
species reactivitymouse, rat, human
浓度~2 mg/mL
technique(s)immunocytochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 4-8 μg/mL using total cell extracts of NIH3T3 fibroblast cell or SW480 cell extract
同位素/亚型IgG1
UniProt登记号Q9UQL6
运输dry ice
储存温度−20℃
Gene Informationhuman ... HDAC5(10014)
mouse ... Hdac5(15184)
rat ... Hdac5(84580)

Sigma-Aldrich

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