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Matrix Metalloproteinase-7 human

品牌
Sigma-Aldrich
货号
M4565
规格纯度
~0.1 mg/mL, recombinant, expressed in E. coli, buffered aqueous solution
参考价格
6360.77 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Matrix metalloproteinase-7 (MMP7) also referred to as matrilysin is encoded by the gene mapped to human chromosome 11q21-q22. MMP7 is a smallest member of MMP enzyme family and is highly expressed in cancer cells. MMP7 is exclusively released by epithelial cells.

应用

Matrix metalloproteinase-7 (MMP7) human has been used in in silico analysis of MMP-7 proteolysis of perlecan.

生化/生理作用

Matrix metalloproteinase-7 (MMP-7) catalyzes the cleavage of extracellular matrix (ECM) proteins such as proteoglycans, fibronectin, entactin, laminin, collagen III/ IV/ V/ IX/ X/ XI, type I/ II/ IV/ V gelatins, and elastin. Matrix metalloproteinase-7 facilitates initial stages of tumor progression. Activated MMP7 plays a vital role in human colorectal cancer (CRC) liver metastases. Overexpression of MMP7 is observed in various human cancers, such as breast, lung, prostate, esophagus, stomach, endometrium, and ovarian carcinomas, as well as esophageal squamous cell carcinomas. Increased expression of MMP7 is also associated with pathogenesis of demyelinating multiple sclerosis (MS) lesions. Both in silico and in vitro studies show that MMP7 degrades glycosylated and basement membrane bound perlecan and plays a vital role in prostate cancer cell invasion.

外形

Solution in 10 mM HEPES, 5 mM CaCl2, 150 mM NaCl

分析说明

One unit of enzyme activity is defined as the digestion of 1 μg of azocoll/min. at pH 7.5 and 37 ℃.

基本信息

酶学委员会(EC)编号3.4.24.23 ( BRENDA | IUBMB )
MDL编号MFCD01633460
NACRESNA.32

产品性质

质量水平200
重组expressed in E. coli
形式buffered aqueous solution
specific activity5,000 units/mg protein
分子量 20 kDa
浓度~0.1 mg/mL
UniProt登记号P09237
相关疾病cancer
运输dry ice
储存温度−70℃
Gene Informationhuman ... MMP7(4316)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

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