产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
GSK2801 is a potent inhibitor of the BAZ2 family of bromodomain containing proteins. BAZ2A is an essential component of the nucleolar remodeling complex (NoRC), which mediates recruitment of histone modifying enzymes and DNA methylase involved in the silencing of ribosomal RNA transcription. BAZ2B is believed to be involved in regulating nucleosome mobilization along linear DNA. For full characterization details, please visit the GSK2801 probe summary on the Structural Genomics Consortium (SGC) website.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
特点和优势
GSK2801 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
其他说明
Light sensitive
GSK2801 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the GSK2801 probe summary on the Chemical Probes Portal website.
基本信息
| 经验(实验)分子式 | C20H21NO4S |
| 分子量 | 371.45 |
| MDL编号 | MFCD26142953 |
| PubChem化学物质编号 | 329825595 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 储存条件 | protect from light |
| 颜色 | , white to pink to light brown |
| 溶解性 | DMSO: 10 mg/mL, clear |
| 储存温度 | −20℃ |
| SMILES string | CCCOC1=CC2=C(C3=CC=CC=C3S(=O)(C)=O)C=C(C(C)=O)N2C=C1 |
| InChI | 1S/C20H21NO4S/c1-4-11-25-15-9-10-21-18(14(2)22)13-17(19(21)12-15)16-7-5-6-8-20(16)26(3,23)24/h5-10,12-13H,4,11H2,1-3H3 |
| InChI key | KHWCPNJRJCNVRI-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 |
| 危险分类 | Acute Tox. 4 Oral |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
