产品说明
应用
Salermide was used to treat human pulmonary artery smooth muscle cells to study the effect of SIRT1 inhibition on expression of atrogin by qPCR.1
包装
5, 25 mg in glass bottle
生化/生理作用
Salermide is a novel Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) inhibitor (III histone deacetylases inhibitor). In vitro Salermide has a stronger inhibitory effect on Sirt2 than on Sirt1. Salermide induces massive apoptosis in tumor cells. The activity was ascribed to effect of Salermide to the reactivation of proapoptotic genes epigenetically repressed exclusively in cancer cells by Sirt1. Salermide is a stronger Sirtuin inhibitor than sirtinol (Cat. No.S7942).
特点和优势
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基本信息
| 经验(实验)分子式 | C26H22N2O2 |
| 分子量 | 394.47 |
| MDL编号 | MFCD12912446 |
| PubChem化学物质编号 | 329824611 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 储存条件 | desiccated |
| 颜色 | yellow |
| 溶解性 | DMSO: >10 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | CC(C(=O)Nc1cccc(c1)\N=C\c2c(O)ccc3ccccc23)c4ccccc4 |
| InChI | 1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30)/b27-17+ |
| InChI key | HQSSEGBEYORUBY-WPWMEQJKSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
