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R(+)-Verapamil monohydrochloride hydrate

R(+)-维拉帕米 单盐酸盐 水合物

品牌
Sigma-Aldrich
CAS
38176-02-2
货号
V106
规格纯度
≥98% (HPLC), powder
参考价格
3154.07 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry. It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity.

包装

5, 25 mg in glass bottle

生化/生理作用

Verapamil is a calcium channel blocker. Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias. It is water soluble in nature.
Inhibitor of P-glycoprotein; less active enantiomer of (±)-verapamil.

注意

hygroscopic

基本信息

经验(实验)分子式C27H38N2O4 · HCl · xH2O
分子量491.06 (anhydrous basis)
EC 号205-800-5
MDL编号MFCD11046028
PubChem化学物质编号24900706
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
旋光性[α]22/D +9.6°, c = 0.5 in ethanol(lit.)
储存条件desiccated
颜色 white
溶解性H2O: >30 mg/mL
ethanol: soluble
SMILES stringO.Cl.COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC
InChI1S/C27H38N2O4.ClH.H2O/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H;1H2/t27-;;/m1../s1
InChI keyICKXRKHJKXMFLR-KFSCGDPASA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H301 + H311 + H331
预防措施声明P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
危险分类Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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