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AMTB hydrate

品牌
Sigma-Aldrich
CAS
926023-82-7
货号
SML0103
规格纯度
≥98% (HPLC)
参考价格
1682.59 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

AMTB hydrate has been used as an inhibitor of transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer cells and murine T cells.

包装

5, 25 mg in glass bottle

生化/生理作用

AMTB is a 2-benzyloxy-benzoic acid amide derivative, which also inhibits voltage-gated sodium channels (Nav) and their isoforms.
AMTB is a TRPM8-selective antagonist with no cross reactivity to TRPV1 or 4. The pIC50 of icilin activation of TRPM8 is 6.23 i.v. administration of AMTB reduced the frequency of rhythmic contractions in volume-loaded bladder and inhibited blood pressure and visceromotor reflex responses to bladder distention.

基本信息

经验(实验)分子式C23H26N2O2S·HCl · xH2O
分子量430.99 (anhydrous basis)
PubChem化学物质编号329825160
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色 white to tan
溶解性DMSO: ≥10 mg/mL
储存温度2-8℃
SMILES stringO=C(C1=C(OCC2=C(C)C=CC=C2)C=CC=C1)N(CCCN)CC3=CC=CS3.Cl.O
InChI1S/C23H26N2O2S.ClH.H2O/c1-18-8-2-3-9-19(18)17-27-22-12-5-4-11-21(22)23(26)25(14-7-13-24)16-20-10-6-15-28-20;;/h2-6,8-12,15H,7,13-14,16-17,24H2,1H3;1H;1H2
InChI keyRTYVTAQFASBIDN-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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