产品介绍：
产品说明
应用
NPS2143 hydrochloride has been used to study the function of calcium-sensing receptor :
- In the regulation of intestinal calcium transport.
- In the regulation of local negative feedback of intestinal calcium absorption.
- In sensorimotor decision making during development.
包装
5, 25 mg in glass bottle
生化/生理作用
NPS2143 is a phenylalkylamine calcilytic compound, and might be useful in treating autosomal dominant hypocalcemia. It serves as a blocking agent for hERG (human ether-a-go-go-related gene ) channel, CYP2D6 (cytochrome P450 2D6 ) and monoamine transporters.
NPS2143 is a selective calcium-sensing receptor (CaR) antagonist. The compound blocks increases in cytoplasmic calcium concentrations with an IC50 of 43 nM, and stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells over a wide range of extracellular calcuim concentrations.
基本信息
| 经验(实验)分子式 | C24H25ClN2O2 · HCl |
| 分子量 | 445.38 |
| MDL编号 | MFCD16038896 |
| PubChem化学物质编号 | 329825364 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 旋光性 | [α]20/D +20 to +24°, c = 1.0 in methanol |
| 颜色 | white to beige |
| 溶解性 | DMSO: >10 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | Cl.CC(C)(Cc1ccc2ccccc2c1)NC[C@@H](O)COc3cccc(Cl)c3C#N |
| InChI | 1S/C24H25ClN2O2.ClH/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26;/h3-12,20,27-28H,13,15-16H2,1-2H3;1H/t20-;/m1./s1 |
| InChI key | ZEBNDUQLNGYBNL-VEIFNGETSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H302 + H312 + H332 - H410 |
| 预防措施声明 | P261 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 |
| 危险分类 | Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
