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ML218

3,5-Dichloro-N-[[(1α,5α,6-exo,6α)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]benzamide

品牌
Sigma-Aldrich
CAS
1346233-68-8
货号
SML0385
包装型号
规格纯度
≥98% (HPLC)
参考价格
1843.44 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

ML218 has been used as a:

  • T-type channel blocker to test its effect on the nociceptive behavior associated with homocysteinemia rats
  • T-type voltage-sensitive calcium channel (VSCC) inhibitor in osteoblasts
  • T-type calcium channel blocker to test its effect on the viability of neural progenitor cells

包装

5, 25 mg in glass bottle

生化/生理作用

ML218 (CID 45115620) is a potent and selective T-Type (Cav3.1, Cav3.2, Cav3.3) calcium channel inhibitor (Cav3.2, IC50 = 150 nM in Ca2+ flux; Cav3.2 IC50 = 310 nM and Cav3.3 IC50 = 270 nM with good Drug metabolism/Pharmacokinetics. In a panel of 68 GPCRs, ion channels and transporters, ML218 was found to bind significantly only two other targets (sodium channel site 2 and sigma 1) and had no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. It showed robust inhibition of calcium current in STN neurons and was orally active in a rodent model of Parkinson′s Disease.

特点和优势

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式C19H26Cl2N2O
分子量369.33
PubChem化学物质编号329825385
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 10 mg/mL (clear solution)
储存温度2-8℃
SMILES stringCC(C)(C)CCN1C[C@H]2C(CNC(=O)c3cc(Cl)cc(Cl)c3)[C@H]2C1
InChI1S/C19H26Cl2N2O/c1-19(2,3)4-5-23-10-16-15(17(16)11-23)9-22-18(24)12-6-13(20)8-14(21)7-12/h6-8,15-17H,4-5,9-11H2,1-3H3,(H,22,24)/t15-,16-,17+
InChI keyGSJIGYLGKSBYBC-OSYLJGHBSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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