产品介绍：
产品说明
应用
CI 976 has been used as an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor:
- to analyze its anti-hepatitis C virus (HCV) activity in Huh7.5.1 cells
- to treat Neuro-2a cells to test its effect on plasma membrane integrated density of α4-SEPβ2 or α6-SEPβ2β3 nicotinic acetylcholine receptors (nAChRs)
- to study its effects on the anti-angiogenic activity of pyripyropenes in human umbilical vein endothelial cells
包装
5 mg in glass bottle
生化/生理作用
CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.
基本信息
| 经验(实验)分子式 | C23H39NO4 |
| 分子量 | 393.56 |
| MDL编号 | MFCD00869662 |
| PubChem化学物质编号 | 329775044 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | >98% (HPLC) |
| 形式 | solid |
| 溶解性 | DMSO: >10 mg/mL H2O: insoluble <2 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC |
| InChI | 1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25) |
| InChI key | WAFNZAURAWBNDZ-UHFFFAOYSA-N |
安全信息
| 危险声明 | H413 |
| 危险分类 | Aquatic Chronic 4 |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
