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CI 976

品牌
Sigma-Aldrich
CAS
114289-47-3
货号
C3743
规格纯度
>98% (HPLC), solid
参考价格
2264.41 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

CI 976 has been used as an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor:

  • to analyze its anti-hepatitis C virus (HCV) activity in Huh7.5.1 cells
  • to treat Neuro-2a cells to test its effect on plasma membrane integrated density of α4-SEPβ2 or α6-SEPβ2β3 nicotinic acetylcholine receptors (nAChRs)
  • to study its effects on the anti-angiogenic activity of pyripyropenes in human umbilical vein endothelial cells

包装

5 mg in glass bottle

生化/生理作用

CI-976, a new trimethoxy fatty acid anilide, is a potent and specific inhibitor of liver and intestinal acyl coenzyme A; cholesterol acyltransferase (ACAT) in vitro. CI-976 decreased non-high density lipoprotein (HDL)-cholesterol and increased HDL-cholesterol in rats with pre-established dyslipidemia. High performance gel chromatographic separation of plasma lipoproteins also revealed that CI-976, but not CL 277,082, lowered low density lipoprotein (LDL)-cholesterol and elevated HDL-cholesterol.

基本信息

经验(实验)分子式C23H39NO4
分子量393.56
MDL编号MFCD00869662
PubChem化学物质编号329775044
NACRESNA.77

产品性质

质量水平100
测定>98% (HPLC)
形式solid
溶解性DMSO: >10 mg/mL
H2O: insoluble <2 mg/mL
储存温度2-8℃
SMILES stringCCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC
InChI1S/C23H39NO4/c1-7-8-9-10-11-12-13-14-15-23(2,3)22(25)24-21-19(27-5)16-18(26-4)17-20(21)28-6/h16-17H,7-15H2,1-6H3,(H,24,25)
InChI keyWAFNZAURAWBNDZ-UHFFFAOYSA-N

安全信息

危险声明H413
危险分类Aquatic Chronic 4
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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