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Phenylmethylsulfonyl Fluoride-CAS 329-98-6-Calbiochem

产品介绍:

产品说明

一般描述

Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor, see AEBSF (Cat. No. 101500).
Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. Effective at a concentration of 50 µM.

包装

1 g in Alu drum
5 g in Glass bottle
25 g in Fibre case

生化/生理作用

Product does not compete with ATP.
Reversible: no
Primary Target
serine proteases
Cell permeable: no

警告

Toxicity: Corrosive (L)

重悬

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
t½ = 1 hour at pH 7.5. Effective concentration: 50 μM.

其他说明

Seitz, R., et al. 1993. Int. J. Cancer53, 514.
Weaver, V.M., et al. 1993. Biochem. Cell. Biol.71, 488.
Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol.316, 427.
Chang, C.T., et al. 1992. Biochem. Int.28, 707.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C7H7FO2S
分子量174.19
MDL编号MFCD00007424
NACRESNA.77

产品性质

质量水平200
测定≥99% (GC)
形式crystalline solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated
颜色 white to off-white
溶解性ethanol: soluble
isopropanol: soluble
methanol: soluble
运输ambient
储存温度10-30℃
InChI1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
InChI keyYBYRMVIVWMBXKQ-UHFFFAOYSA-N

安全信息

象形图GHS05GHS06
警示用语:Danger
危险声明H301 - H314
预防措施声明P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
危险分类Acute Tox. 3 Oral - Skin Corr. 1B
储存分类代码6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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