产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
TUG-424 is expected to be useful in the exploration of FFA1 and may also be valuable as a lead structure for new potential antidiabetic therapeutics. TUG-424 significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity. It enhanced glucose-stimulated insulin secretion in a rat beta-cell line already at 100 nM and from isolated mouse islets through FFA1.
GPR40 (now FFA1) was formerly an orphan GPCR whose endogenous ligands have recently been identified as free fatty acids (FFAs). The receptor appears to be involved in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release.
基本信息
| 经验(实验)分子式 | C18H16O2 |
| 分子量 | 264.32 |
| MDL编号 | MFCD12912449 |
| PubChem化学物质编号 | 329826854 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 溶解性 | DMSO: >10 mg/mL H2O: insoluble |
| 储存温度 | 2-8℃ |
| SMILES string | Cc1ccccc1C#Cc2ccc(CCC(O)=O)cc2 |
| InChI | 1S/C18H16O2/c1-14-4-2-3-5-17(14)12-10-15-6-8-16(9-7-15)11-13-18(19)20/h2-9H,11,13H2,1H3,(H,19,20) |
| InChI key | FODHWOBAQBTTFS-UHFFFAOYSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H319 - H410 |
| 预防措施声明 | P264 - P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391 |
| 危险分类 | Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
