产品介绍：
产品说明
应用
SB265610 has been used:
- as a cysteine-amino acid-cysteine (CXC)-chemokine receptor type 2 (CXCR2) antagonist to study its effects on the binding of chemokine with G-protein coupled receptors (GPCR)
- as a CX-chemokine receptor type 1 (CXCR1) inhibitor to study its effect on the chemotactic activity of chemokines on inflammatory cells
- as a CXCR2 antagonist to study its effect on migration of neutrophils to the rat brain
包装
5, 25 mg in glass bottle
生化/生理作用
SB265610 is a potent and selective CXCR2 chemokine receptor antagonist. It has a Kd = 2.5 nM.
特点和优势
This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
基本信息
| 经验(实验)分子式 | C14H9BrN6O |
| 分子量 | 357.16 |
| MDL编号 | MFCD09971124 |
| PubChem化学物质编号 | 329825416 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to light brown |
| 溶解性 | DMSO: 15 mg/mL, clear |
| 储存温度 | 2-8℃ |
| SMILES string | Brc1ccccc1NC(=O)Nc2ccc(C#N)c3nn[nH]c23 |
| InChI | 1S/C14H9BrN6O/c15-9-3-1-2-4-10(9)17-14(22)18-11-6-5-8(7-16)12-13(11)20-21-19-12/h1-6H,(H2,17,18,22)(H,19,20,21) |
| InChI key | SEDUMQWZEOMXSO-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H302 |
| 危险分类 | Acute Tox. 4 Oral |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
