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Prinomastat hydrochloride

普马司他 盐酸盐

品牌
Sigma-Aldrich
CAS
192329-42-3
货号
PZ0198
规格纯度
≥95% (HPLC)
参考价格
1237.51 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Prinomastat comprises hydroxamic acid group and chelates with zinc ion.

应用

Prinomastat hydrochloride has been used as an antagonist for metalloproteinases (MMPs) in Crotalus atrox venom samples and mouse embryo cultures. It may be used as a MMP-2 inhibitor in HepG2 cells.

包装

5, 25 mg in glass bottle

生化/生理作用

Prinomastat is a matrix metalloprotease (MMP) inhibitor with selectivity for MMPs 2, 3, 9, 13, and 14. Inhibition of these MMPs has been postulated to block tumor invasion and metastasis. It is extremely potent at MMP-3 and MMP-2 with IC50s, 30 pM & 50 pM, respectively.

其他说明

This compound was developed by Pfizer for Cytoskeleton & Extracellular Matrix research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式C18H21N3O5S2 · HCl
分子量459.97
PubChem化学物质编号329823770
NACRESNA.77

产品性质

质量水平100
测定≥95% (HPLC)
形式powder
manufacturer/tradenamePfizer®
颜色 white to beige
溶解性H2O: 15 mg/mL (clear solution)
创始人Pfizer
储存温度room temp
SMILES stringCl.CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c2ccc(Oc3ccncc3)cc2
InChI1S/C18H21N3O5S2.ClH/c1-18(2)16(17(22)20-23)21(11-12-27-18)28(24,25)15-5-3-13(4-6-15)26-14-7-9-19-10-8-14;/h3-10,16,23H,11-12H2,1-2H3,(H,20,22);1H/t16-;/m0./s1
InChI keyUQGWXXLNXBRNBU-NTISSMGPSA-N

安全信息

象形图GHS08
警示用语:Danger
危险声明H360
预防措施声明P201 - P308 + P313
危险分类Repr. 1B
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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