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Safinamide mesylate salt

品牌
Sigma-Aldrich
CAS
202825-46-5
货号
SML0025
规格纯度
≥98% (HPLC)
参考价格
1202.81 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Safinamide mesylate salt has been used as a reference drug to study its inhibitory effect on human monoamine oxidases (hMAO-A and hMAO-B).
Safinamide mesylate salt may be used in cell signaling studies.

包装

5, 25 mg in glass bottle

生化/生理作用

Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.
Safinamide mesylate prevents dopamine reuptake and is effective in the treatment of epilepsy and Parkinson′s disease.

特点和优势

This compound is featured on the Calcium Channels and Dopamine and Norepinephrine Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式C17H19FN2O2 · xCH4O3S
分子量302.34 (free base basis)
MDL编号MFCD15145475
PubChem化学物质编号329825096
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
旋光性[α]/D +9.5 to +14°, c = 1 (95% acetic acid)
颜色 white to tan
溶解性H2O: ≥15 mg/mL
储存温度2-8℃
SMILES stringCS(O)(=O)=O.C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O
InChI1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1
InChI keyYKOCHIUQOBQIAC-YDALLXLXSA-N
Gene Informationhuman ... MAOB(4129)

安全信息

象形图GHS07GHS08
警示用语:Warning
危险声明H302 - H319 - H361d
预防措施声明P202 - P264 - P270 - P301 + P312 - P305 + P351 + P338 - P308 + P313
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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