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d9A-2

N-(14-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-3,6,9,12-tetraoxatetradecan-1-yl)-4′-fluoro-3′-methyl-2-[4-(4-methyl-1H-imidazol-5-yl)piperidin-1-yl]-[1,1′-biphenyl]-4-carboxamide

品牌
Sigma-Aldrich
货号
SML2978
规格纯度
≥98% (HPLC)
参考价格
1076.74 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

d9A-2 is a potent degrader (PROTAC) of the solute carrier SLC9A1 impairs recovery from acid load and is potently cytotoxic to multiple cancer cell lines. Also, d9A-2 incites degradation of some SLC9 members including closely related SLC9A2 and SLC9A4, distant SLC9A7 and SLC9B1. d9A-2 comprise w9A ligand binding to SLC9A1 and the phthalimide-based CRBN binder.

基本信息

经验(实验)分子式C46H54FN7O9
分子量867.96

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringO=C(CCC1N2C(C(C=CC=C3NCCOCCOCCOCCOCCNC(C4=CC(N5CCC(C6=C(C)N=CN6)CC5)=C(C7=CC=C(F)C(C)=C7)C=C4)=O)=C3C2=O)=O)NC1=O

安全信息

WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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