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CBR-5884

品牌
Sigma-Aldrich
CAS
681159-27-3
货号
SML1656
规格纯度
≥98% (HPLC)
参考价格
1117.23 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

CBR-5884 has been used as a 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor to explore the role of PHGDH in Müller cells from different retinal regions and also used in trypan blue exclusion assay to determine the number of viable MYCN cells.

包装

5, 25 mg in glass bottle

生化/生理作用

CBR-5884 is a cell penetrant, potent and selective noncompetitive inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH) that inhibits proliferation of melanoma and breast cancer lines. CBR-5884 inhibits de novo serine synthesis in in cancer cells.

基本信息

经验(实验)分子式C14H12N2O4S2
分子量336.39
PubChem化学物质编号329825995

产品性质

质量水平100
测定≥98% (HPLC)
形式paste
颜色 white to beige
溶解性DMSO: 20 mg/mL, clear
储存温度2-8℃
SMILES stringCC1=C(C(OCC)=O)SC(NC(C2=CC=CO2)=O)=C1SC#N
InChI1S/C14H12N2O4S2/c1-3-19-14(18)11-8(2)10(21-7-15)13(22-11)16-12(17)9-5-4-6-20-9/h4-6H,3H2,1-2H3,(H,16,17)
InChI keyQBVIRPJBDIZKBC-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319 - H335
预防措施声明P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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