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AP-18

品牌
Sigma-Aldrich
CAS
55224-94-7
货号
A7232
规格纯度
≥98% (HPLC), solid
参考价格
1249.07 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

AP-18 is a selective TRPA1 channel blocker. AP-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. AP-18 reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. AP-18 reverses CFA-induced mechanical hyperalgesia in mice

包装

5, 25 mg in glass bottle

生化/生理作用

AP-18 is a selective TRPA1 channel blocker. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. AP-18 reverses CFA-induced mechanical hyperalgesia in mice.

基本信息

经验(实验)分子式C11H12ClNO
分子量209.67
MDL编号MFCD00102250
PubChem化学物质编号329770922
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
颜色 white to off-white
溶解性DMSO: >10 mg/mL
储存温度2-8℃
SMILES stringCC(=C/c1ccc(Cl)cc1)\C(C)=N\O
InChI1S/C11H12ClNO/c1-8(9(2)13-14)7-10-3-5-11(12)6-4-10/h3-7,14H,1-2H3/b8-7+,13-9+
InChI keyMHTJEUOFLVQMCL-NJHPPEEMSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302
预防措施声明P264 - P270 - P301 + P312 - P501
危险分类Acute Tox. 4 Oral
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Sigma-Aldrich

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