产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
AA74-1 is an extremely potent and selective inhibitor of the serine hydrolase acyl-peptide hydrolase (APEH) with an IC50 of 5 nM in mouse T-cell proteomes. AA74-1 potently blocked the activity of its target serine hydrolase, APEH, in mice in vivo without significantly affecting other enzymes. The APEH inhibition caused accumulation of N-acetylated proteins and stimulated cellular proliferation in T cells.
The APEH gene is deleted in some cancers, in which it has been proposed to serve as a potential tumor suppressor, and is involved in the degradation of oligomeric amyloid-beta which could make it a new target for therapy aimed at reducing neurodegeneration in Alzheimer′s disease. AA74-1 is the first selective tool for studying APEH activity.
基本信息
| 经验(实验)分子式 | C16H28N4O2 |
| 分子量 | 308.42 |
| MDL编号 | MFCD23704789 |
| PubChem化学物质编号 | 329825360 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | film |
| 颜色 | colorless |
| 溶解性 | DMSO: >15 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | CC(C)CC(O)(CC(C)C)c1cnn(n1)C(=O)N2CCCC2 |
| InChI | 1S/C16H28N4O2/c1-12(2)9-16(22,10-13(3)4)14-11-17-20(18-14)15(21)19-7-5-6-8-19/h11-13,22H,5-10H2,1-4H3 |
| InChI key | GXBVPGCIMCIASQ-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
