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VU0238429

品牌
Sigma-Aldrich
CAS
1160247-92-6
货号
V4515
规格纯度
solubility: ≥20 mg/mL in DMSO
参考价格
1221.42 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency. M5 is thought to regulate cerebral blood flow, and activation of M5 may be therapeutic for Alzheimer′s disease. VU0238429 is the first reported M5-selective small molecule of any kind. It is >30-fold more selective for M5 over M1, M2, M3, and M4.

特点和优势

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式C17H12F3NO4
分子量351.28
MDL编号MFCD16618396
PubChem化学物质编号329829052
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 orange
溶解性DMSO: ≥20 mg/mL
储存温度2-8℃
SMILES stringCOc1ccc(CN2C(=O)C(=O)c3cc(OC(F)(F)F)ccc23)cc1
InChI1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3
InChI keyCKLGZXFOLMHCMC-UHFFFAOYSA-N

安全信息

象形图GHS07GHS09
警示用语:Warning
危险声明H319 - H400
预防措施声明P273 - P305 + P351 + P338
危险分类Aquatic Acute 1 - Eye Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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