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(Z)-Endoxifen

品牌
Sigma-Aldrich
货号
SML2368
规格纯度
≥98% (HPLC)
参考价格
1896.25 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

(Z)-Endoxifen has been used to demonstrate the lack of contribution of subventricular zone and leptomeningeal cells in a study determining the generation of neuroblasts from astrocytes.

生化/生理作用

(Z)-Endoxifen (endoxifen) is an active tamoxifen metabolite generated via actions of cytochrome P450 (CYP) enzymes CYP3A4/5 and CYP2D6. Endoxifen is more potent than tamoxifen as a selective estrogen receptor modulator (SERM) both in vitro and in vivo with good pharmacokinetics and oral availability (∼80% MCF-7 tumor growth inhibition with 4-8 mg/kg/day endoxifen or 20 mg/kg/day tamoxifen in mice via p.o.). Endoxifen also exhibits 4-fold higher PKC inhibitory potency than tamoxifen and can overcome tamoxifen resistance due to cytochrome CYP2D6 polymorphism.

基本信息

经验(实验)分子式C25H27NO2
分子量373.49
MDL编号MFCD09840374

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃

安全信息

象形图GHS09
警示用语:Warning
危险声明H400
预防措施声明P273 - P391 - P501
危险分类Aquatic Acute 1
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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