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VU0155069

品牌
Sigma-Aldrich
CAS
1130067-06-9
货号
SML2279
规格纯度
≥98% (HPLC)
参考价格
798.09 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

VU0155069 is a PLD1-selective catalytic site-targeting phospholipase D inhibitor (PLD1/2 IC50 = 46 nM/933 nM by cell-free enzymatic assays; substrate = di-palmitoyl-PLC) that selectively suppresses the cellular PLD activity in PMA-stimulated non-small-cell lung cancer (NSCLC) Calu-1 cells with predominant PLD1 activity over GFP-PLD2-overexpressing HEK293 cells (IC50 = 11 nM and 1.8 μM, respectively). Note: VU0155069 is reported to impair P2X7-induced pore formation in human RPMI 8226 B cells lacking PLD1 expression.

基本信息

经验(实验)分子式C26H27ClN4O2
分子量462.97
MDL编号MFCD23160355
NACRESNA.77

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to beige
储存温度2-8℃
SMILES stringO=C(C1=CC=C2C=CC=CC2=C1)N[C@@H](C)CN3CCC(N4C5=CC=C(Cl)C=C5NC4=O)CC3

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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