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Tonabersat

品牌
Sigma-Aldrich
CAS
175013-84-0
货号
SML1354
规格纯度
≥98% (HPLC)
参考价格
1827.35 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

Tonabersat (SB-220453) exhibits anticonvulsant property. It is a member of the family of novel benzoylamino-benzopyran compounds. Tonabersat is used as a therapeutic for trigeminal nerve-induced neurovascular reflexes. In addition, it acts as a putative migraine prophylactic agent containing an unique stereospecific binding site in the brain.
Tonabersat is a potent inhibitor of neuronal-glial gap junctions in trigeminal ganglion that inhibits cortical spreading depression (CSD) and neurogenic inflammation in animal models of migraine.

基本信息

经验(实验)分子式C20H19ClFNO4
分子量391.82
MDL编号MFCD00944458
PubChem化学物质编号329825809
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
旋光性[α]/D -100 to -110°, c = 1 in methanol
颜色 white to beige
溶解性DMSO: 20 mg/mL, clear
储存温度2-8℃
SMILES stringCC(C1=CC=C2C([C@H](NC(C3=CC=C(F)C(Cl)=C3)=O)[C@H](O)C(C)(C)O2)=C1)=O
InChI1S/C20H19ClFNO4/c1-10(24)11-5-7-16-13(8-11)17(18(25)20(2,3)27-16)23-19(26)12-4-6-15(22)14(21)9-12/h4-9,17-18,25H,1-3H3,(H,23,26)/t17-,18-/m0/s1
InChI keyXLIIRNOPGJTBJD-ROUUACIJSA-N

安全信息

象形图GHS07GHS09
警示用语:Warning
危险声明H315 - H319 - H400
预防措施声明P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391
危险分类Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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