产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
Tonabersat (SB-220453) exhibits anticonvulsant property. It is a member of the family of novel benzoylamino-benzopyran compounds. Tonabersat is used as a therapeutic for trigeminal nerve-induced neurovascular reflexes. In addition, it acts as a putative migraine prophylactic agent containing an unique stereospecific binding site in the brain.
Tonabersat is a potent inhibitor of neuronal-glial gap junctions in trigeminal ganglion that inhibits cortical spreading depression (CSD) and neurogenic inflammation in animal models of migraine.
基本信息
经验(实验)分子式 | C20H19ClFNO4 |
分子量 | 391.82 |
MDL编号 | MFCD00944458 |
PubChem化学物质编号 | 329825809 |
NACRES | NA.77 |
产品性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | powder |
旋光性 | [α]/D -100 to -110°, c = 1 in methanol |
颜色 | white to beige |
溶解性 | DMSO: 20 mg/mL, clear |
储存温度 | 2-8℃ |
SMILES string | CC(C1=CC=C2C([C@H](NC(C3=CC=C(F)C(Cl)=C3)=O)[C@H](O)C(C)(C)O2)=C1)=O |
InChI | 1S/C20H19ClFNO4/c1-10(24)11-5-7-16-13(8-11)17(18(25)20(2,3)27-16)23-19(26)12-4-6-15(22)14(21)9-12/h4-9,17-18,25H,1-3H3,(H,23,26)/t17-,18-/m0/s1 |
InChI key | XLIIRNOPGJTBJD-ROUUACIJSA-N |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H315 - H319 - H400 |
预防措施声明 | P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391 |
危险分类 | Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 |
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |