产品说明
一般描述
Chemical structure: sulfonamide
应用
Sulfameter is a sulfonamide antibiotic used as a leprostatic agent and to treat urinary tract infections. It has been investigated as a potential therapy for chloroquine-resistant malaria during pregnancy.
包装
5 g in poly bottle
生化/生理作用
Sulfameter is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Sulfameter is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
其他说明
Keep container tightly closed in a dry and well-ventilated place. Light sensitive.
基本信息
| 经验(实验)分子式 | C11H12N4O3S |
| 分子量 | 280.30 |
| Beilstein | 621130 |
| EC 号 | 211-480-8 |
| MDL编号 | MFCD00006067 |
| PubChem化学物质编号 | 24899422 |
| NACRES | NA.85 |
产品性质
| 质量水平 | 200 |
| 形式 | powder |
| 储存条件 | (Keep container tightly closed in a dry and well-ventilated place. Light sensitive.) |
| 颜色 | white to faint yellow |
| 作用机制 | enzyme | inhibits |
| 抗生素抗菌谱 | Gram-negative bacteria Gram-positive bacteria mycobacteria parasites |
| 储存温度 | 2-8℃ |
| SMILES string | COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1 |
| InChI | 1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15) |
| InChI key | GPTONYMQFTZPKC-UHFFFAOYSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H315 - H319 - H335 |
| 预防措施声明 | P302 + P352 - P305 + P351 + P338 |
| 危险分类 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| 靶器官 | Respiratory system |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
