产品说明
生化/生理作用
SCH 79797 aids protection during ischemic injury. During subarachnoid hemorrhage (SAH), it plays a key role in the maintenance of microvascular integrity. SCH 79797 also elicits pro‐apoptotic and antiproliferative effects.
SCH 79797 is a nonpeptidic antagonist that targets protease activated receptor-1 (PAR-1) with high affinity (IC50 = 70 nM against 10 nM haTRAP in competitive binding assay; Ki = 35 nM) and selectively inhibits PAR-1 agonists-induced human platelet aggregation (IC50 = 300 nM and 3 μM against 300 nM haTRAP and 0.1 U/mL α-thrombin, respectively), while exhibiting little potency against platelet aggregation induced by ADP, collagen, or PAR-4 agonist γ-thrombin. SCH-79797 is shown to display neuroprotective and antiepileptogenic efficacy in a rat model of lithium/pilocarpine-induced status epilepticus (SE) in vivo (25 μg/kg via daily i.p. 20-30 min after SE termination).
基本信息
经验(实验)分子式 | C23H25N5 · xHCl |
分子量 | 371.48 (free base basis) |
NACRES | NA.77 |
产品性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | powder |
储存条件 | desiccated |
颜色 | white to light brown |
溶解性 | DMSO: 2 mg/mL, clear |
储存温度 | room temp |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |