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PF-03491165

(βR,dR)-5-Cyclopropyl-2-(4-fluorophenyl)-4-[[[(3-fluorophenyl)methyl]amino]carbonyl]-β,d-dihydroxy-1H-imidazole-1-heptanoic acid

品牌
Sigma-Aldrich
CAS
950741-95-4
货号
PZ0404
规格纯度
≥98% (HPLC)
参考价格
780.67 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

PF-03491165 is a potent HMG-CoA reductase inhibitor (IC50 = 0.1 nM) with good hepatoselectivity (rat hepatocyte/myocyte cholesterol synthesis IC50 = 0.1 nM/444 nM). PF-03491165 exhibits superior plasma low density lipoprotein (LDL)-lowering efficacy than rosuvastatin and pravastatin in Guinea pigs in vivo (EC50 = 5.9, 13.5, 73.3 mg/kg, respectively via daily po) despite its low oral bioavailability in rats and dogs.

基本信息

经验(实验)分子式C27H29F2N3O5
分子量513.53

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃
SMILES stringFC1=CC=C(C=C1)C2=NC(C(NCC3=CC=CC(F)=C3)=O)=C(N2CC[C@H](C[C@H](CC(O)=O)O)O)C4CC4

Sigma-Aldrich

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