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Lometrexol hydrate

品牌
Sigma-Aldrich
CAS
106400-81-1
货号
SML0040
规格纯度
≥95% (HPLC)
参考价格
2895.22 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Lometrexol hydrate was used to compare the biological activity of potent inhibitor of human GARFTase.

包装

5, 25 mg in glass bottle

生化/生理作用

Glycinamide Ribonucleotide Formyltransferase (GARFTase) is a folate-dependent enzyme required for de novo purine synthesis. Lometrexate is a potent inhibitor of GARFTase, but does not interfere with enzymes involved in the synthesis of folate. Lometrexerol has been tested clinically for the treatment of various cancers as an anti-folate like agent, similar to methotrexate. Treatment with lometrexol rapidly decreases ATP and GTP levels, cell cycle arrest and induces apoptosis. Although depletion of nucleotide pools induces p53 expression, lometrexol is cytotoxic in both wild-type and mutant p53 expressing tumor cells. Lometrexol is cytotoxic in CCRF-CEm leukemia cells with an IC50 of 2.9 nM.

基本信息

经验(实验)分子式C21H25N5O6 · xH2O
分子量443.45 (anhydrous basis)
PubChem化学物质编号329825110

产品性质

质量水平100
测定≥95% (HPLC)
形式powder
颜色 white to light yellow
溶解性DMSO: ≥5 mg/mL
储存温度2-8℃
SMILES stringO.NC1=NC(=O)C2=C(NC[C@H](CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)C2)N1
InChI1S/C21H25N5O6.H2O/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28;/h3-6,12,15H,1-2,7-10H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30);1H2/t12-,15+;/m1./s1
InChI keyAEFQSKJUVDZANQ-YLCXCWDSSA-N

安全信息

象形图GHS06
警示用语:Danger
危险声明H301
预防措施声明P301 + P310
危险分类Acute Tox. 3 Oral
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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