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Isoforskolin

6β-Acetoxy-1α,7β,9α-trihydroxy-8,13-epoxy-labd-14-en-11-one

品牌
Sigma-Aldrich
CAS
64657-21-2
货号
SML2801
规格纯度
≥95% (HPLC)
参考价格
841.96 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Isoforskolin is a naturally occurring diterpene with anti-inflammatory activity. It has been shown to downregulate the expression of proinflammatory compounds. In an experimental mouse model of Lyme Disease induced arthritis isoforskolin downregulated the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In a rat asthmatic model isoforskolin down-regulated production of transforming growth factor β1 (TGF-β1) and interleukin-1β (IL-1β) which was accompanied by inhibition of inflammation and airway remodeling.

基本信息

经验(实验)分子式C22H34O7
分子量410.50
MDL编号MFCD00078929

产品性质

质量水平100
测定≥95% (HPLC)
形式powder
旋光性[α]/D -8 to -5°, c = 0.5 in chloroform-d
颜色 white to beige
溶解性DMF:H2O (9:1): 2 mg/mL, clear
储存温度−20℃
SMILES stringCC(=O)O[C@@H]1[C@H](O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)C13)C=C
InChI1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16?,17-,19-,20-,21+,22-/m0/s1
InChI keyCLOQVZCSBYBUPB-VDCUXWMXSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H312
预防措施声明P280 - P302 + P352 + P312 - P362 + P364 - P501
危险分类Acute Tox. 4 Dermal
储存分类代码11 - Combustible Solids
WGKWGK 3

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