位置:首页 > 品牌 > Sigma-Aldrich >

LUF7346

品牌
Sigma-Aldrich
CAS
1821638-40-7
货号
SML1927
包装型号
规格纯度
≥98% (HPLC)
参考价格
2102.31 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

5, 25 mg in glass bottle

生化/生理作用

LUF7346 has the ability to enhance the potassium current (IKr) in a heterologous system. It is found to be highly effective than other human ether-a-go-go-related gene (hERG) activators, such as Rottlerin and NS1643.
LUF7346 is a Kv11.1 (hERG) allosteric modulator that prevents proarrhythmic effects caused by hERG blockers in rat ventricular myocyte cultures. LUF7346 reduces Kv11.1 (ERG) affinity toward known Kv11.1 channel blockers dofetilide (Ki for hERG = 4.8 nM without and 12 nM with 10 μM LUF7346) and astemizole (Ki for for hERG = 1.3 nM without and 5.3 nM with 10 μM LUF7346) and effectively suppresses astemizole-induced arrhythmogenic events in a dose-dependent manner among Long-QT syndrome/LQTS (LQT1, JLNS, LQT2) and control isogenic human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). LUF7346 is shown to slow IKr deactivation and positively shifts IKr inactivation among LQTS and control isogenic hiPSC-CMs without affecting KCNQ1/KCNE1-dependent IKs or L-type calcium current ICaL.

基本信息

经验(实验)分子式C20H15BrN2O3
分子量411.25
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 10 mg/mL, clear
储存温度2-8℃
SMILES stringO=C(NC1=CC=CN=C1)COC2=CC=C(C(C3=C(Br)C=CC=C3)=O)C=C2

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号