位置:首页 > 品牌 > Sigma-Aldrich >

HET0016

品牌
Sigma-Aldrich
CAS
339068-25-6
货号
SML2416
规格纯度
≥95% (HPLC)
参考价格
768.57 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

HET0016 is a potent and selective inhibitor against cytochrome P450 (CYP450) ω-hydroxylases (human CYP4A11/4A22/4F2/4F3, rat CYP4A1/4A2/4A3/4A8)-mediated 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis (IC50 = 8.9/35 nM using human/rat renal microsomes), exhibiting much reduced potency against epoxyeicosatrienoic acids (EETs) biosynthesis (IC50 = 2.8 μM/rat microsome) or the enzyme activities of CYP2C9/2D6/3A4 and COX (IC50 = 3.3/83.9/71 μM and 2.3 μM). HET0016 is widely employed both in cultures (1-10 μM) and in aminals in vivo (1-10 mg/kg via i.v., i.m., i.p. or s.c.) for probing 20-HETE-dependent physiological and pathological processes.

基本信息

经验(实验)分子式C12H18N2O
分子量206.28

产品性质

测定≥95% (HPLC)
形式powder
储存条件desiccated
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度−20℃
SMILES stringCCCCC1=CC=C(C(C)=C1)/N=C/NO

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号