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CCT007093

品牌
Sigma-Aldrich
CAS
176957-55-4
货号
C9369
规格纯度
≥98% (HPLC), powder, yellow
参考价格
1156.54 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

CCT007093 has been used as a wild-type p53-induced phosphatase (Wip1) inhibitor to study its effect on skin keratinocytes, under ultra-violet (UV) stress conditions. It has also been used as a Wip1 inhibitor in time course inhibition assay to evaluate the effect of Wip1 inhibition on expression of AKT serine/threonine kinase 1(Akt1) and glycogen synthase kinase-3β (GSK-3β)and the phosphorylation of GSK-3β at serine 9 (Ser9) and Akt at Ser473.

包装

5, 25 mg in glass bottle

生化/生理作用

CCT007093 inhibits the growth of cancer cell lines (MCF-7, KPL-1, and MCF-3B) that overexpress protein phosphatase, Mg2+/Mn2+ dependent 1D (PPM1D). It induces cancer cell death via the activation of p38 kinase activity.
CCT007093 is an effective protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D) inhibitor that selectively reduces viability of human tumour cell lines.

特点和优势

This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式C15H12OS2
分子量272.39
MDL编号MFCD00121546
PubChem化学物质编号329775204
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式powder, yellow
溶解性DMSO: >3 mg/mL
储存温度2-8℃
SMILES stringO=C1\C(CC\C1=C/c2cccs2)=C\c3cccs3
InChI1S/C15H12OS2/c16-15-11(9-13-3-1-7-17-13)5-6-12(15)10-14-4-2-8-18-14/h1-4,7-10H,5-6H2/b11-9+,12-10+
InChI keyKPFZCKDPBMGECB-WGDLNXRISA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319 - H335
预防措施声明P302 + P352 - P305 + P351 + P338
危险分类Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

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