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A-769662

4-Hydroxy-3-(2′-hydroxy-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile

品牌
Sigma-Aldrich
CAS
844499-71-4
货号
SML2578
规格纯度
≥98% (HPLC)
参考价格
937.96 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

A-769662 is a potent, β1 subunit-selective, allosteric drug and metabolite (ADaM) site AMPK activator (α1β1γ1 EC50/Emax = 0.15 μM/1.99 vs. 4.51 μM/2.19 with AMP) that promotes a Thr172 phosphorylation in a β1 carbohydrate binding module (CBM) Ser108 phosphorylation-dependent manner. A769662 synergizes with AMP as well as C2 (AMP mimetic) toward Thr172 dephosphorylated/Ser108 phosphorylated AMPK. A-769662 is widely employed in probing AMPK β1 complexes-mediated cellular signaling in cultures (conc range: 1 μM-1 mM) as well as AMPK-dependent physiological and pathological processes in mice and rats in vivo (dosing range: 1-30 mg/kg i.p.).

基本信息

经验(实验)分子式C20H12N2O3S
分子量360.39
MDL编号MFCD11977269

产品性质

测定≥98% (HPLC)
形式powder
颜色 white to very dark brown
溶解性DMSO: 2 mg/mL, clear
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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