产品介绍：
产品说明
应用
2OHOA has been used as:
- a modulator of the sphingolipid and glycerophospholipid pathway to study its effects on myelination in mice Charcot–Marie–Tooth type 1A (CMT1A) myelinopathy and myelinating dorsal root ganglia cultures
- in biophysical studies to study its effects on artificial membranes
- to study its interactions with major membrane lipid films
包装
5, 25 mg in glass bottle
生化/生理作用
2-Hydroxy oleic acid (2OHOA) is a derivative of oleic acid. It plays a role in membrane organization, alterations in membrane fluidity, an increase of the tendency to form non-lamellar structures, and remodeling of microdomains by interacting with the lipids in membranes of pathological cells.
2OHOA induces cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2OHOA increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.
基本信息
| 经验(实验)分子式 | C18H34O3 |
| 分子量 | 298.46 |
| MDL编号 | MFCD07778553 |
| PubChem化学物质编号 | 329825264 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 储存条件 | protect from light |
| 颜色 | white to tan |
| 溶解性 | DMSO: >20 mg/mL |
| 储存温度 | room temp |
| SMILES string | CCCCCCCC\C=C/CCCCCCC(O)C(O)=O |
| InChI | 1S/C18H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21/h9-10,17,19H,2-8,11-16H2,1H3,(H,20,21)/b10-9- |
| InChI key | JBSOOFITVPOOSY-KTKRTIGZSA-N |
安全信息
| 象形图 |  |
| 警示用语： | Danger |
| 危险声明 | H318 |
| 预防措施声明 | P280 - P305 + P351 + P338 |
| 危险分类 | Eye Dam. 1 |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
