位置:首页 > 品牌 > Sigma-Aldrich >

A-350619 hydrochloride

品牌
Sigma-Aldrich
货号
A6604
规格纯度
≥98% (HPLC), solid
参考价格
2104.92 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Guanylyl cyclases are signal transduction enzyme that convert GTP to cyclic GMP. Soluble guanylate cyclase is activated by a gaseous ligand, nitric oxide.. The nitric oxide activation of soluble guanylate, resulting in GTP conversion to GMP, is important in physiological processes such as as smooth muscle relaxation, neurotransmission, inhibition of platelet aggregation and immune response. A-350619 is an activator of soluble guanylyl cyclase.

应用

A-350619 relaxes cavernosum tissue strips in a dose dependent manner with EC50 of 80 μMM. Because A-350619 at 1 μMmol/kg induces penile erection in a conscious rat model, it may be useful as an alternate method of enhancing the effect of nitric oxide for the treatment of sexual dysfunction.

包装

5 mg in glass bottle

生化/生理作用

A-350619 modulates catalytic properties of soluble guanylyl cyclase; it increases Vmas from 0.1 to 14.5 μmol/min/mg and lowers Km from 300 to 50 μM. A-350619 activation of soluble guanylate cyclase depends on the presence of a heme moiety in the enzyme and synergy with nitric oxide.

特点和优势

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

法律信息

Sold under license from Abbott Laboratories

基本信息

经验(实验)分子式C21H25ClN2OS · HCl
分子量425.41
MDL编号MFCD06798332
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
颜色 white
mp175.2-176.7 ℃
溶解性H2O: 23 mg/mL
创始人Abbott
储存温度2-8℃

安全信息

象形图GHS05GHS07GHS09
警示用语:Danger
危险声明H302 - H315 - H318 - H335 - H410
预防措施声明P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号