产品说明
生化/生理作用
WT-1, the product of Wilms′ tumor suppressor gene Wt1, is a nuclear protein with structural motifs characteristic of transcription factors, including four C-terminal zinc fingers. While different pre-mRNA processing could result in 16 isoforms of the protein, the inclusion or exclusion of exon 5 and three amino acids (KTS) between zinc fingers 3 and 4 largely affects the activity of the WT1 protein. Such a complex post-transcriptional regulation, particularly in splicing, may represent a major regulatory mechanism for tumorigenesis of the Wilms′ tumor. With the inclusion of exon 5, WT1 (KTS+) binds to both DNA and RNA and is RNase but not DNase sensitive. This form also co-localizes with splicing factors in a speckled nuclear particle, suggesting that the WT1 protein may function as both a transcription factor and a splicing regulator.
外形
Clear and colorless frozen liquid solution
制备说明
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
基本信息
NACRES | NA.26 |
产品性质
生物来源 | human |
重组 | expressed in insect cells |
测定 | ≥60% (SDS-PAGE) |
形式 | frozen liquid |
包装 | pkg of 5 μg |
储存条件 | avoid repeated freeze/thaw cycles |
浓度 | 150 μg/mL |
颜色 | clear colorless |
NCBI登记号 | NM_024425 |
UniProt登记号 | P19544 |
运输 | dry ice |
储存温度 | −70℃ |
Gene Information | human ... WT1(7490) |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |