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WT-1 (+KTS) human

品牌
Sigma-Aldrich
货号
SRP2082
规格纯度
recombinant, expressed in insect cells, ≥60% (SDS-PAGE)
参考价格
7847.18 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

WT-1, the product of Wilms′ tumor suppressor gene Wt1, is a nuclear protein with structural motifs characteristic of transcription factors, including four C-terminal zinc fingers. While different pre-mRNA processing could result in 16 isoforms of the protein, the inclusion or exclusion of exon 5 and three amino acids (KTS) between zinc fingers 3 and 4 largely affects the activity of the WT1 protein. Such a complex post-transcriptional regulation, particularly in splicing, may represent a major regulatory mechanism for tumorigenesis of the Wilms′ tumor. With the inclusion of exon 5, WT1 (KTS+) binds to both DNA and RNA and is RNase but not DNase sensitive. This form also co-localizes with splicing factors in a speckled nuclear particle, suggesting that the WT1 protein may function as both a transcription factor and a splicing regulator.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in insect cells
测定≥60% (SDS-PAGE)
形式frozen liquid
包装pkg of 5 μg
储存条件avoid repeated freeze/thaw cycles
浓度150 μg/mL
颜色clear colorless
NCBI登记号NM_024425
UniProt登记号P19544
运输dry ice
储存温度−70℃
Gene Informationhuman ... WT1(7490)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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