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PF-06282999

品牌
Sigma-Aldrich
CAS
1435467-37-0
货号
PZ0375
包装型号
规格纯度
≥98% (HPLC)
参考价格
1311.9 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

PF-06282999 is an orally active thiouracil class myeloperoxidase (MPO) suicide substrate (kinact/KI = 11600 M-1s-1) that targets MPO heme group for mechanism-based irreversible inactivation wtih high selectivity over thyroid peroxidase (TPO kinact/KI <3 M-1s-1) and heme-containing cytochrome P450 (CYP) isoforms (IC50 >100 μM). PF-06282999 effectively inhibits MPO activity in human blood stimulated by LPS ex vivo (IC50 = 1.9 μM) and in blood of LPS-treated cynomolgus monkeys in vivo (5-80 mg/kg p.o. 1hr post LPS i.v.) with good pharmacokinetics and oral availability (100%/86%/75%/76% in mice/rats/dogs/monkeys). PF-06282999 also exhibits weak PXR activating activity (EC50/Emax = 279 μM/9.36-fold vs.0.8 μM/19.6-fold with rifampin).

法律信息

Sold for research purposes under agreement from Pfizer Inc
Pfizer is a registered trademark of Pfizer, Inc.

基本信息

经验(实验)分子式C13H12ClN3O3S
分子量325.77
MDL编号MFCD30533689
NACRESNA.77

产品性质

测定≥98% (HPLC)
形式powder
manufacturer/tradenamePfizer®
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
创始人Pfizer
储存温度room temp
SMILES stringO=C(N)CN(C(N1)=S)C(C2=CC(Cl)=CC=C2OC)=CC1=O

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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