位置:首页 > 品牌 > Sigma-Aldrich >

Ginkgolic Acid (15:1)-CAS 22910-60-7-Calbiochem

品牌
Sigma-Aldrich
CAS
22910-60-7
货号
345887
规格纯度
A cell-permeable anacardic acid analog that inhibits protein SUMO .
参考价格
5238.04 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable anacardic acid (Cat. No. 172050) analog that inhibits protein SUMO (Cat. Nos. 662037, 662039, and 662042) modification (IC50 = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. Nos. 662073 and 662074) and interfering with E1-SUMO intermediate formation independent of E1 active site cysteine. Both ginkgolic acid and anacardic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins, including p53, in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although both compounds are shown to inhibit histone lysine acetylation by PCAF (Cat. No. 124026) in cell-free acetylase assays. Also available as a 25 mM solution in DMSO (Cat. No. 508197).
A cell-permeable anacardic acid (Cat. No. 172050) analog that inhibits protein SUMO (Cat. No. 662037, 662039, and 662042) modification (IC50 = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. No. 662073 and 662074) and interfering with E1-SUMO intermediate formation independent of E1 active site cysteine. Both ginkgolic acid and anacardic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins, including p53, in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although both compounds are shown to inhibit histone lysine acetylation by PCAF (Cat. No. 124026) in cell-free acetylase assays.

包装

5 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Irritant (B)

重悬

Following intitial thaw, aliquot and freeze (-20°C).

其他说明

Fukuda, I., et al. 2009. Chem. Biol.16, 133.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C22H34O3
分子量346.50
MDL编号MFCD03093717

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性DMSO: 100 mg/mL
ethanol: 100 mg/mL
运输ambient
储存温度−20℃
InChI1S/C22H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h7-8,15,17-18,23H,2-6,9-14,16H2,1H3,(H,24,25)/b8-7-
InChI keyYXHVCZZLWZYHSA-FPLPWBNLSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H317 - H413
预防措施声明P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
危险分类Aquatic Chronic 4 - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)509.9 °F - (calculated)
闪点(C)265.5 ℃ - (calculated)

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号