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PRMT Inhibitor VII, DB867-Calbiochem

品牌
Sigma-Aldrich
货号
5.06046
规格纯度
A cell-permeable, selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 9.5 μM).
参考价格
2023.95 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC50 = 110 µM) and PRMT6 (IC50 = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC50 = 110 µM) and PRMT6 (IC50 = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.

生化/生理作用

Primary Target
PRMT1
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他说明

Xu, J., et al, 2013. Mol. Cell.51, 1.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C17H15NO5
分子量313.30

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
效能9 μM IC50
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 yellow
溶解性10% acetic acid: 5 mg/mL
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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