产品说明
一般描述
A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC50 = 110 µM) and PRMT6 (IC50 = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
A cell-permeable biscarboxamidine derivative that acts as a selective inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 9.5 µM). Exhibits about 10-fold greater selectivity over PRMT5 (IC50 = 110 µM) and PRMT6 (IC50 = 118 µM). Shown to block BMP4-induced phosphorylation and activation of Smad1/Smad5 and asymmetric dimethylation of Arg3 on histone 4 (H4R3) in HaCaT cells transfected with PRMT1.
生化/生理作用
Primary Target
PRMT1
Reversible: yes
包装
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
其他说明
Xu, J., et al, 2013. Mol. Cell.51, 1.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C17H15NO5 |
分子量 | 313.30 |
产品性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | solid |
效能 | 9 μM IC50 |
manufacturer/tradename | Calbiochem® |
储存条件 | OK to freeze protect from light |
颜色 | yellow |
溶解性 | 10% acetic acid: 5 mg/mL |
储存温度 | 2-8℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |