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TLR8 Agonist, cpd14b-Calbiochem

品牌
Sigma-Aldrich
货号
5.30409
规格纯度
A potent agonist of Toll-like receptor 8 agonist (TLR8, EC50 = 200 nM).
参考价格
2394.05 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A pentyl-quinoline derived compound that acts as a pure, potent agonist of Toll-like receptor 8 agonist (TLR8, EC50 = 200 nM in a human TLR8-specifc reporter gene assay). Does not affect TLR2, 3, 4, 5, 7, 9, 10, Nod1 and Nod2, and is devoid of any TLR7 activity. Shown to induce activities of several cytokines and chemokines, including IL-1a, IL-1b, IL-6, IL-8, IL-10, IL12, IL-18, IFN-g, CCL20, RANTES, GRO, GM-CSF, and Eotaxin (~ 10 mg/ml).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
A pentyl-quinoline derived compound that acts as a pure, potent agonist of Toll-like receptor 8 agonist (TLR8, EC50 = 200 nM in a human TLR8-specifc reporter gene assay). Does not affect TLR2, 3, 4, 5, 7, 9, 10, Nod1 and Nod2, and is devoid of any TLR7 activity. Shown to induce activities of several cytokines and chemokines, including IL-1a, IL-1b, IL-6, IL-8, IL-10, IL12, IL-18, IFN-g, CCL20, RANTES, GRO, GM-CSF, and Eotaxin (~ 10 mg/ml).

生化/生理作用

Cell permeable: yes
Primary Target
TLR8
Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他说明

Kokatla, H. P., et al. 2014, ChemMedChem9, 719.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C14H18N2
分子量214.31

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性DMSO: 100 mg/mL
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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